Widespread intron retention in mammals functionally tunes transcriptomes
نویسندگان
چکیده
منابع مشابه
SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage.
Spinal muscular atrophy (SMA), an autosomal recessive neuromuscular disease, is the leading monogenic cause of infant mortality. Homozygous loss of the gene survival of motor neuron 1 (SMN1) causes the selective degeneration of lower motor neurons and subsequent atrophy of proximal skeletal muscles. The SMN1 protein product, survival of motor neuron (SMN), is ubiquitously expressed and is a key...
متن کاملWidespread intronic polyadenylation diversifies immune cell transcriptomes
Irtisha Singh1,2, Shih-Han Lee3, Mehmet K. Samur4, Yu-Tzu Tai4, Nikhil C. Munshi4, Christine Mayr3# and Christina S. Leslie1# 1Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 2Tri-I Program in Computational Biology and Medicine, Weill Cornell Graduate College, New York, NY 3Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York,...
متن کاملGenomic organization of transcriptomes in mammals: Coregulation and cofunctionality.
In studies of their transcriptional activity, genomes have shown a high order of organization. We assessed the question of how genomically neighboring genes are transcriptionally coupled across tissues and what could be the driving force behind their coupling. We focused our analysis on the transcriptome information for 13 tissues of Mus musculus and 79 tissues of Homo sapiens. The analysis of ...
متن کاملWidespread intron loss suggests retrotransposon activity in ancient apicomplexans.
Several facets of spliceosomal intron in apicomplexans remain mysterious. First, intron numbers vary across species by 2 orders of magnitude, indicating massive intron loss and/or gain. Second, previous studies have shown very different evolutionary patterns over different timescales, with 100-fold higher rates of intron loss/gain between genera than within genera. Third, the timing and dynamic...
متن کاملRESEARCH ARTICLES AVery High Fraction of Unique Intron Positions in the Intron-Rich Diatom Thalassiosira pseudonana Indicates Widespread Intron Gain
Although spliceosomal introns are present in all characterized eukaryotes, intron numbers vary dramatically, from only a handful in the entire genomes of some species to nearly 10 introns per gene on average in vertebrates. For all previously studied intron-rich species, significant fractions of intron positions are shared with other widely diverged eukaryotes, indicating that 1) large numbers ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Research
سال: 2014
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.177790.114